文献摘要

耳硬化症鐙骨手術時發生鼓膜穿孔之預後
Outcomes After Tympanic Membrane Perforation During Primary Stapes Surgery for Otosclerosis

Volume 5, Issue 1

關鍵字 :
耳硬化症,中耳,耳科學/耳神經學, Otosclerosis, middle ear, otology/neurotology

作者 :
Alexander L. Luryi, MD ; Amy Schettino, MD; Elias M. Michaelides, MD; Seilesh Babu, MD ; Dennis I. Bojrab, MD ; Christopher A. Schutt, MD

譯者 :
高雄長庚醫院 楊昭輝醫師

摘要:


Objective/Hypothesis: Stapes surgery is occasionally complicated by an intraoperative tympanic membrane perforation (ITMP), traditionally indicating abortion of the procedure due to concerns for postoperative infection and sensorineural hearing loss (SNHL). This work examines outcomes and complications in completed primary stapes surgeries with and

without ITMP.


Study Design: Retrospective review.


Methods: All patients diagnosed with otosclerosis between February 2008 and September 2017 at a tertiary otology referral center were reviewed retrospectively. Primary outcome measures were post-operative air-bone gap (ABG), air conduction and bone conduction pure tone averages, and post-operative complications.


Results: Review revealed 652 primary stapes operations meeting inclusion criteria, of which ITMP occurred in 10. There were no significant differences in pre-operative hearing metrics or demographic characteristics between ears with and without ITMP. There were also no significant differences in post-operative ABG (6.4 vs. 8.0 dB HL, P = .43) or change in ABG after surgery (−21.6 vs. −18.2 dB, P = .34) between these two groups. Patients with ITMP were more likely to complain of postoperative dysgeusia (30.0% vs. 5.3%, P = .015) but were no more likely to develop reparative granuloma, otitis media, or SNHL (P > .05).


Conclusions: The first review of ITMP and hearing outcomes after stapes surgery is presented. Our findings suggest that it is likely safe and appropriate to proceed with primary stapes surgery and concurrent tympanoplasty in the presence of a small ITMP with minimal risk of infection, SNHL, or worsened hearing outcomes.

專家評論:


耳硬化症鐙骨手術時發生鼓膜穿孔之預後


高雄長庚醫院 楊昭輝醫師


耳硬化症病患的聽力常隨著疾病進展逐漸變差,需藉由助聽器輔助或手術治療恢復聽力。針對耳硬化症的鐙骨手術成效十分卓越,然而極少數仍有可能發生聽力下降或全聾的風險。在手術過程中,掀起鼓膜耳道皮瓣(Tympanomeatal flap)的動作可能會傷害到鼓膜而造成鼓膜穿孔,在顧慮到可能造成中耳腔感染的情況下,有些醫師會中止手術等待鼓膜癒合後再做鐙骨手術。然而,在近年來越來越精緻的中耳手術技術下,是否仍需有此項顧慮是這篇論文作者想要釐清的重點。此研究的目的在評估鐙骨手術術中發生鼓膜穿孔患者術後之聽力狀況與發生併發症的機會是否較高。


作者回溯性分析2008年2月至2017年9月間,Michigan Ear Institute 587例(652耳)因耳硬化症接受鐙骨手術的病患,其中有10耳(1.5%)在術中發生鼓膜穿孔(intraoperative tympanic membrane perforation, ITMP),642耳沒有鼓膜穿孔(No ITMP)。兩組患者間的年齡、性別、左右患病耳、麻醉方式以及BMI等分佈並無差異,兩組術前的氣導閾值(AC threshold)以及氣骨導差(Air-bone gap)也沒有統計差異。ITMP組中有9例(90%)為小於25%鼓膜大小的小型穿孔,所有ITMP組均在手術中使用顳肌膜(temporalis fascia)做underlay修補。手術後的氣導閾值及骨氣導差進步的幅度,兩組之間均無明顯差別,術後發生感覺神經性聽力損失(定義為術後的骨導閾值增加15分貝),在No ITMP組為7個病人(佔1.1%),ITMP組中並未有術後感音性聽力損失,兩組並無統計學上的顯著差異。在術後併發症方面,發生術後味覺異常及耳部出血的比例,ITMP發生的比例明顯較No ITMP組來的高(P<0.05)。


傳統鐙骨手術的觀念,認為鼓膜穿孔可能會有造成病患術後發生迷路炎及感覺神經性聽力損失的風險,因此若術中發現鼓膜穿孔建議終止手術,然而近代的鐙骨手術普遍認為手術仍可繼續進行。此篇文獻為第一篇針對此議題的研究,證實術中的鼓膜穿孔並不影響術後的聽力改善及併發症的發生,其結論並不令人意外。ITMP組其術後發生味覺異常及耳部出血的比例較高,可能是因為將鼓膜翻破的醫師多是手術資歷比較資淺或是訓練中的住院醫師,也因此會有比較高的機會發生傷及鼓索神經和鼓膜耳道皮瓣造成味覺異常及耳部出血的情況,不過作者並沒有統計ITMP組執行醫師的手術經驗。另外,筆者比較有興趣的主題是原先已有鼓膜穿孔的耳硬化症患者,是否能在鐙骨手術時同時修補鼓膜,此篇研究並沒有列入分析,或許目前大多數的耳科醫師還是會將原有慢性中耳炎的鼓膜穿孔先修復後,再安排鐙骨手術之進行。


此篇分析單一中心一年半內施行的652耳鐙骨手術,比台灣的鐙骨手術數量多出許多,但發生術中鼓膜穿孔的僅有十例,因此此篇研究會因為ITMP組數目較少而影響其統計結果,且回溯型分析會產生許多資料收集時的偏差。不過這篇文章至少提供一些數據,讓手術資歷比較資淺的醫師在進行鐙骨手術時,若不慎造成鼓膜穿孔,不至於太過擔心術後的手術成效。


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