文献摘要

全喉切除術後使用大腿前外側皮瓣重建發聲管的說話表現
Speech Performance after Anterolateral Thigh Phonatory Tube Reconstruction for Total Laryngectomy

Volume 5, Issue 1

關鍵字 :
喉癌,下咽癌,全喉切除術,說話,大腿前外側皮瓣重建, Laryngeal cancer, total laryngectomy, speech, ALT flap

作者 :
Yi-An Lu, MD; Yu-Cheng Pei, MD, PhD; Hsiu-Feng Chuang, MS; Li-Yun Lin, BS; Li-Jen Hsin, MD; Chung-Jan Kang, MD; Shiang-Fu Huang, MD, PhD; Hui-Chen Chiang, PhD; Chung-Kan Tsao, MD; Tuan-Jen Fang, MD

譯者 :
林口長庚醫院 林婉妮醫師 盧怡安醫師

摘要:


Objective: Traditionally, after total laryngopharyngectomy (TLP), patients cannot speak without a prosthesis or an artificial larynx. In Taiwan, most patients use a commercialized pneumatic laryngeal device (PLD). Phonatory tube reconstruction with the anterolateral thigh (ALT) flap is a novel, modified version of synchronous digestive and phonatory reconstruction involving a free muscular cutaneous flap. This study reviewed and compared speech performance between patients who underwent novel flap reconstruction and conventional PLD users.


Method: We retrospectively reviewed patients with laryngeal or hypopharyngeal cancer who underwent TLP from August 2017 toSeptember  2019. The voice handicap index (VHI), speech intelligibility, acoustic and aerodynamic analysis results, and speech range profile (SRP) were compared between patients who underwent ALT phonatory tube reconstruction (ALT group) and those using PLDs (PLD group).


Results: Twenty patients were included; 13 patients were included in the ALT group, and 7 patients were included in the PLD group. Compared to the PLD group, the ALT group had a better fundamental frequency range (P < .001) and semitone range (P < .001) during speech but showed worse jitter, shimmer, and harmonic-to-noise ratios. The two groups showed comparable VHI and speech intelligibility performance.


Conclusions: The ALT phonatory tube, a novel flap for reconstruction, can restore digestive and voice functions simultaneously. Compared with PLD use, ALT phonatory tube reconstruction yields an improved speech range and comparable levels of voice handicap and speech intelligibility, suggesting that the technique is a good alternative for patients after TLP.

專家評論:


全喉切除術後使用大腿前外側皮瓣重建發聲管的說話表現


林口長庚醫院 林婉妮醫師


盧怡安醫師


治療進行性(advanced)喉癌及下咽癌的同時要兼顧保留病患的音聲及吞嚥功能在臨床上極具挑戰,在這些病患之中有30~40%的病患會接受全喉切除手術(total laryngopharyngectomy),因此如何在術後保留說話功能更顯重要。術後的音聲復健方式可使用人工喉(artificial larynxes)發聲,例如氣動式發聲器(pneumatic larynx devices)及電子喉發聲器(electrolarynxes),也可以使用食道語(esophageal speech)或者使用氣管食道發生瓣(tracheoesophageal prostheses)。在台灣,大部分病患使用氣動式發聲器,不過各種發聲方式在使用上的方便性及吵雜環境裡溝通上的困難開始被注意,在近年來病患的生活品質及社會參與也越來越受到重視。

  

關於全喉切除手術後的皮瓣重建,大腿前外側皮瓣因為有較好的皮瓣存活率以及較低的感染率而很常被使用,Revenaugh et al. 曾經報告大腿前外側皮瓣重建合併氣管食道發生瓣(tracheoesophageal prostheses)有很好的發聲結果,而我們發展出大腿前外側皮瓣合併重建發聲管(anterolateral thigh phonatory tube reconstruction),靈感源自於氣管食道分流(tracheoesophageal shunt),是一項可以同時重建吞嚥及發聲的新型改良技術,我們假設大腿前外側皮瓣重建發聲管有良好的發聲說話成果,而許多研究已報導氣動式發聲器的發聲說話流暢易懂而且成功率高,因此本研究比較大腿前外側皮瓣重建發聲管與氣動式發聲器的發聲說話表現。

 

本篇研究回朔性分析2017年8月至2019年9月間,林口長庚醫院共20位病患,其中13位病患在全喉切除手術後接受大腿前外側皮瓣重建發聲管(ALT group),另外7位病患則是接受傳統皮瓣重建並且使用氣動式發聲器說話(PLD group)。測量方式包含嗓音障礙量表(voice handicap index),言語清晰度(speech intelligibility),音聲及氣動力學分析(voice acoustic and phonatory aerodynamic analyses)及言語音域範圍(speech range profile)。結果發現ALT group說話時相較PLD group,言語音域範圍有比較寬的基頻範圍(fundamental frequency range )(P < .001)與半音範圍(semitone range)(P < .001);不過在音聲及氣動力學分析方面,ALT group有較差的頻率擾動係數(jitter),震幅擾動係數(shimmer)及諧音噪音比(harmonic-to-noise ratios)。其他在嗓音障礙量表及言語清晰度評估,兩組則有相當的表現。

    

此篇文獻顯示大腿前外側皮瓣重建發聲管的語言表現相對氣動式發聲器在擾動係數及諧音噪音比表現較差但不影響言語清晰度。另外,大腿前外側皮瓣重建發聲管有頻率範圍變化的優勢,這在過去英語系文獻中未曾發表過,尤其台灣使用的語言為中文是一種四聲調的語言,語調的改變對於能否流暢溝通更為重要,因此大腿前外側皮瓣重建發聲管對於全喉切除之後的病患是一個很不錯的重建音聲的選項。不過因為此為回朔性研究,之後需要收集更多前瞻性的研究,以長期追蹤病患隨著時間及復健過程言語音聲的改變,也需要進一步比較跟其他音聲復健方式例如食道語或氣管食道發生瓣的發聲語言表現。此篇文章內有較詳細的手術設計圖片示意,附件中有兩組音聲檔可供參考,全喉切除病患術後的音聲復健需要跨科團隊,治療師及病患一起努力,也希望病患能夠得到更好的生活及溝通品質。



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